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carmustine (bis-chloroethylnitrosourea, bcnu, bicnu) is a medication used mainly for chemotherapy. it is a nitrogen mustard ß-chloro-nitrosourea compound used as an alkylating agent.
description
carmustine is an orange-yellow solid medication used mainly for chemotherapy. it is a nitrogen mustard ß-chloro-nitrosourea compound.
mechanism of action
as an alkylating agent, carmustine can form interstrand crosslinks in dna, which prevents dna replication and dna transcription.needed]
uses
carmustine is used as an alkylating agent to treat several types of brain cancer including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma), multiple myeloma, and lymphoma (hodgkin’s and non-hodgkin).
bcnu is sometimes used in conjunction with alkyl guanine transferase (agt) inhibitors, such as o6-benzylguanine. the agt-inhibitors increase the efficacy of carmustine by inhibiting the direct reversal pathway of dna repair, which will prevent formation of the interstrand crosslink between the n1 of guanine and the n3 of cytosine.
it is also used as part of a chemotherapeutic protocol in preparation for hematological stem cell transplantation, a type of bone marrow transplant, in order to reduce the white blood cell count in the recipient. use under this protocol, usually with fludarabine and melphalan, was developed by oncologists at the university of texas md anderson cancer center.needed]
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carmustine (bis-chloroethylnitrosourea, bcnu, bicnu) is a medication used mainly for chemotherapy. it is a nitrogen mustard ß-chloro-nitrosourea compound used as an alkylating agent.
description
carmustine is an orange-yellow solid medication used mainly for chemotherapy. it is a nitrogen mustard ß-chloro-nitrosourea compound.
mechanism of action
as an alkylating agent, carmustine can form interstrand crosslinks in dna, which prevents dna replication and dna transcription.needed]
uses
carmustine is used as an alkylating agent to treat several types of brain cancer including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma), multiple myeloma, and lymphoma (hodgkin’s and non-hodgkin).
bcnu is sometimes used in conjunction with alkyl guanine transferase (agt) inhibitors, such as o6-benzylguanine. the agt-inhibitors increase the efficacy of carmustine by inhibiting the direct reversal pathway of dna repair, which will prevent formation of the interstrand crosslink between the n1 of guanine and the n3 of cytosine.
it is also used as part of a chemotherapeutic protocol in preparation for hematological stem cell transplantation, a type of bone marrow transplant, in order to reduce the white blood cell count in the recipient. use under this protocol, usually with fludarabine and melphalan, was developed by oncologists at the university of texas md anderson cancer center.needed]
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carmustine (bis-chloroethylnitrosourea, bcnu, bicnu) is a medication used mainly for chemotherapy. it is a nitrogen mustard ß-chloro-nitrosourea compound used as an alkylating agent.
description
carmustine is an orange-yellow solid medication used mainly for chemotherapy. it is a nitrogen mustard ß-chloro-nitrosourea compound.
mechanism of action
as an alkylating agent, carmustine can form interstrand crosslinks in dna, which prevents dna replication and dna transcription.needed]
uses
carmustine is used as an alkylating agent to treat several types of brain cancer including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma), multiple myeloma, and lymphoma (hodgkin’s and non-hodgkin).
bcnu is sometimes used in conjunction with alkyl guanine transferase (agt) inhibitors, such as o6-benzylguanine. the agt-inhibitors increase the efficacy of carmustine by inhibiting the direct reversal pathway of dna repair, which will prevent formation of the interstrand crosslink between the n1 of guanine and the n3 of cytosine.
it is also used as part of a chemotherapeutic protocol in preparation for hematological stem cell transplantation, a type of bone marrow transplant, in order to reduce the white blood cell count in the recipient. use under this protocol, usually with fludarabine and melphalan, was developed by oncologists at the university of texas md anderson cancer center.needed]
579183 227523I like the helpful info you offer inside your articles. Ill bookmark your weblog and check once more here regularly. Im quite certain I will learn lots of new stuff appropriate here! Greatest of luck for the next! 483356
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carmustine (bis-chloroethylnitrosourea, bcnu, bicnu) is a medication used mainly for chemotherapy. it is a nitrogen mustard ß-chloro-nitrosourea compound used as an alkylating agent.
description
carmustine is an orange-yellow solid medication used mainly for chemotherapy. it is a nitrogen mustard ß-chloro-nitrosourea compound.
mechanism of action
as an alkylating agent, carmustine can form interstrand crosslinks in dna, which prevents dna replication and dna transcription.needed]
uses
carmustine is used as an alkylating agent to treat several types of brain cancer including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma), multiple myeloma, and lymphoma (hodgkin’s and non-hodgkin).
bcnu is sometimes used in conjunction with alkyl guanine transferase (agt) inhibitors, such as o6-benzylguanine. the agt-inhibitors increase the efficacy of carmustine by inhibiting the direct reversal pathway of dna repair, which will prevent formation of the interstrand crosslink between the n1 of guanine and the n3 of cytosine.
it is also used as part of a chemotherapeutic protocol in preparation for hematological stem cell transplantation, a type of bone marrow transplant, in order to reduce the white blood cell count in the recipient. use under this protocol, usually with fludarabine and melphalan, was developed by oncologists at the university of texas md anderson cancer center.needed]
257477 847549Hello super schner Webblog den ihr da habt. Bin gerade ber die Google Suche darber gestolpert. Gefllt mir echt super gut. macht weiter so. MFG Martina 640237
438591 575359I saw your post awhile back and saved it to my computer. Only recently have I got a chance to checking it and need to let you know nice function. 212016
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